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Conclusion Oxidative stress, driving a cascade of molecular and cellular changes, emerges as a critical factor disrupting the function and integrity of melanocytes

CagriSema would be a co-injection of cagrilintide 2.4 mg and semaglutide 2.4 mg (separate pens initially, with a fixed-combination device planned for later)

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Ultimately, 706 participants met the eligibility criteria and were randomly assigned to one of several treatment arms: once-weekly subcutaneous injections of Cagrilintide at doses of 0.3, 0.6, 1.2, 2.4, or 4.5 mg, once-daily liraglutide 3.0 mg, or a volume-matched placebo